Menopause | Clinicians Corner

The role of cytokines and hot flashes in perimenopausal depression

» By Karaoulanis S, et al

(April 2012) An imbalance in the production of proinflammatory and anti-inflammatory cytokines may play a role in the pathophysiology of perimenopausal depression.

Health symptoms during midlife in relation to menopausal transition: British prospective cohort study

» By Mishra, Gita D., et al

(February 2012) Objective To characterise symptoms experienced by women during the transition into natural menopause, to classify women into distinct symptom profiles or trajectories, and to relate…

Types of ovarian activity in women and their significance: the continuum (a reinterpretation of early findings)

» By James B. Brown

(March–April 2011) There are many types of ovarian activity that occur in women. This review provides information on the relationship between the hormone values and the degree…

Sleep symptoms during the menopausal transition and early postmenopause: observations from the Seattle Midlife Women’s Health Study

» By NF Woods, ES Mitchell

(April 2010) Describe the severity of getting to sleep, nighttime awakening, and early morning awakening across the menopausal transition (MT) and early postmenopause (PM) and their relationship…

Clinical evaluation of women with PMB. Is it always necessary an endometrial biopsy to be performed? A review of the literature

» By Marina Dimitraki, et al

(August 2010) Endometrial carcinoma is the most distressing cause of abnormal vaginal bleeding. The intention of clinical management in the case of postmenopausal bleeding is to achieve…

Association of active and passive smoking with risk of breast cancer among postmenopausal women: a prospective cohort study.

» By Juhua Luo, Karen L Margolis, Jean Wactawski-Wende, Kimberly Horn, Catherine Messina, Marcia L Stefanick, Hilary A Tindle, Elisa Tong, Thomas E Rohan

(March 2011) An examination of the association between smoking and risk of invasive breast cancer using quantitative measures of lifetime passive and active smoking exposure among postmenopausal…

Understanding hypertriglyceridemia in women: clinical impact and management with prescription omega-3-acid ethyl esters.

» By Thomas D Dayspring

(March 2011) Elevated triglycerides (TGs) are a common lipid disorder in the US and are associated with comorbidities such as pancreatitis, obesity, type 2 diabetes, and metabolic…

Breast cancer risk in relation to the interval between menopause and starting hormone therapy.

» By Valerie Beral, Gillian Reeves, Diana Bull, Jane Green and for the Million Women Study Collaborators

(January 2011) Although breast cancer risk is greater in users of estrogen–progestin than estrogen-only formulations of menopausal hormonal therapy, reports on their effects have been…

Can depression be a menopause-associated risk?

» By Claudio N Soares

(December 2010) There is little doubt that women experience a heightened psychiatric morbidity compared to men. A growing body of evidence suggests that, for some women, the…

Premenopausal osteoporosis, an overlooked consequence of anorexia nervosa.

» By Kathryn Teng

(January 2011) Many young women with anorexia nervosa develop premenopausal osteoporosis. This review summarizes factors affecting the development of premenopausal osteoporosis in these patients and identifies potential…